Thwarting protein production slows cancer cells' malignant march
 | Protein production or translation is tightly coupled to a highly conserved stress response —- the heat shock response and its primary regulator, heat shock factor 1 (HSF1) —- that cancer cells rely on for survival and proliferation, according to researchers. In mouse models of cancer, therapeutic inhibition of translation interrupts HSF1's activity, dramatically slowing tumor growth and potentially rendering drug-resistant tumors responsive to other therapies. |
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